Italy, Nov. 18 -- Project Id: 76990
Description: Grant agreement ID: 834634
Status
Ongoing project
Start date
1 September 2019
End date
31 August 2024
Funded under:
H2020-EU.1.1.
Overall budget:
€ 2 450 000
EU contribution
€ 2 450 000
Objective
This proposal intends to shed light on the interplay between cancer immunity and gut microbiome as a way to optimize personalized cancer vaccines and immunotherapy. The project originates from two milestone discoveries. First, to be effective cancer immunotherapies have to target CD4+/CD8+ T cell neo-epitopes, which originate from tumor mutations. Second, the gut microbiome influences the effectiveness of anti-PD-1/PD-L1 antibody immunotherapy both in animal models and in h...