CHICAGO, April 27 -- New results from a clinical trial led by Memorial Sloan Kettering Cancer Center (MSK), gastrointestinal oncologists Andrea Cercek, MD, and Luis Diaz Jr., MD, demonstrate how immunotherapy alone can allow people with MMRd cancers to avoid surgery and preserve their quality of life.

The results, presented at the 2025 American Association of Cancer Research (AACR) Annual Meeting and published simultaneously in The New England Journal of Medicine (NEJM), found that 80% of patients did not require surgery, radiation, or chemotherapy after six months of treatment with immunotherapy alone.

" This study shows that immunotherapy can replace surgery, radiation, and chemotherapy for mismatch repair-deficient solid tumors, whi...