New Delhi, Dec. 19 -- Mohamed Salah has gone for up to a month, costing Liverpool its all-time leading goal-scorer in the Premier League.

Manchester United has lost its most potent attacking force in Bryan Mbeumo, along with two more key figures.

They're nothing compared to Sunderland, a promoted team punching above its weight in England's top flight. It has been decimated by the loss of six players.

The Africa Cup of Nations is taking a toll on the Premier League, with some of its biggest stars heading off to the tournament situated right in the middle of the season. And this weekend is the first round of matches when teams will have to do without those players.

It is unfortunate that AFCON can be cast as a nuisance for many clubs in...