LONDON, Sept. 12 -- Manchester City will be desperate to avoid a third successive defeat when they face neighbours Manchester United as the Premier League returns this weekend, with Alexander Isak set for his Liverpool debut.

City boss Pep Guardiola and United manager Ruben Amorim are both under intense pressure just three games into the season while champions Liverpool boast the top division's only 100 per cent record.

Elsewhere, following the international break, Ange Postecoglou is back in management with Nottingham Forest, just three months after he was sacked by Tottenham.

AFP Sport looks at three key talking points ahead of the weekend's action:

Manchester derby can heal wounds

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