Clinical Trial: Neural and Antidepressant Effects of Propofol (Phase 2)

U.S., April 29 -- ClinicalTrials.gov registry received information related to the study (NCT03923361) titled 'Neural and Antidepressant Effects of Propofol (Phase 2)' on April 19.

Brief Summary: Moderate-intensity propofol treatments will be administered to participants who are non-responders at the end of Phase 1.

Study Type: Interventional

Condition: Treatment Resistant Depression

Intervention: Drug: Diprivan

Similar to the high-intensity propofol treatments in Phase 1, the anesthesiologist will administer an induction dose of propofol followed by a continuous infusion, insert an airway, and begin mechanical ventilation. Propofol dosing will be adjusted with the goal of achieving a burst-suppression state with a SR of 40-60 for 12-15...