U.S., April 18 -- ClinicalTrials.gov registry received information related to the study (NCT03912740) titled 'Effect of Dexmedetomidine on Nol-Index Guided Remifentanil Analgesia' on Feb. 25.
Brief Summary: Background:
Analgesia remains to this day a challenge for anesthesiologists. Dexmedetomidine, a potent central alpha-2 agonist, has been shown to have analgesic and opioid sparing effects. The classic analgesic strategy focuses on opioid administration guided by estimated time of elimination and hemodynamic response (increase in blood pressure and heart rate). This technique is not sensitive and forces the anesthesiologist to be one step behind nociception, the patient's unconscious response to pain.
PMD-200 (Medasense, Israel) displa...