Mumbai, Feb. 24 -- The domestic equity indices traded with major losses in early afternoon trade, primarily driven by mixed global sentiment and a weak handover from the US markets. Concerns over Donald Trump's tariff policies and their potential impact on the US economy, along with reports of a new bat coronavirus strain in China and renewed tensions between Russia and Ukraine, weighed heavily on investor sentiment. The Nifty traded below the 22,600 level. Metal shares declined after advancing for the previous five consecutive trading sessions.

At 12:30 IST, the barometer index, the S&P BSE Sensex, tumbled 787.96 points or 1.05% to 74,523.66. The Nifty 50 index dropped 235.40 points or 1.03% to 22,560.50.

In the broader market, the S&P...