Mumbai, May 13 -- The key equity indices traded with major losses in early afternoon trade, weighed down by profit booking and weakness in index heavyweights, despite easing U.S.-China tensions. The Nifty slipped below the 24,750 mark. Pharma shares witnessed buying demand for the second consecutive trading session.

At 12:25 IST, the barometer index, the S&P BSE Sensex, declined 874.63 points or 1.07% to 81,551.37. The Nifty 50 index slipped 204.75 points or 0.82% to 24,719.95.

In the broader market, the S&P BSE Mid-Cap index rose 0.57% and the S&P BSE Small-Cap index added 1%.

The market breadth was strong. On the BSE, 2,527 shares rose and 1,247 shares fell. A total of 164 shares were unchanged.

Derivatives:

The NSE's India VIX, a ...