Mumbai, Feb. 14 -- The key domestic indices traded with significant losses in the afternoon trade. The Nifty slipped the 22,850 mark after hitting the day's high of 23,133.70 in early trade. All the sectoral indices on the NSE were traded in red with media, pharma and PSU Bank shares witnessing sharpest declines.

At 13:25 IST, the barometer index, the S&P BSE Sensex, declined 485.18 points or 0.64% to 76,644.94. The Nifty 50 index tumbled 182.80 points or 0.79% to 22,848.60.

In the broader market, the S&P BSE Mid-Cap index fell 2.81%, and the S&P BSE Small-Cap index rose dropped 3.57%.

The market breadth was positive. On the BSE, 544 shares rose and 3,337 shares fell. A total of 105 shares were unchanged.

Gainers & Losers:

Nestle Ind...