United Kingdom, May 6 -- Christina Applegate has found living with multiple sclerosis (MS) to be the "worst thing" she's ever experienced.

The 53-year-old actress was diagnosed with MS - a degenerative neurological condition - back in 2021, and Christina admits that living with the autoimmune disease has been the biggest challenge of her life.

During an appearance on the 'Conan O'Brien Needs a Friend' podcast, Christina said: "This is the worst thing I've ever had in my life. It's the worst thing I've ever gone through."

Christina rarely leaves her house these days, as she struggles with her symptoms.

The Hollywood star shared: "If people saw what my life was like on the daily, they wouldn't ... they wouldn't be able to do it. Because...