Ohio, June 15 -- Researchers are working to improve the way we use evolutionary modeling to understand drug resistance. The study uses a "fitness seascape" evolutionary model to predict whether an infection will develop antibiotic resistance. It found that inconsistent timing and missing early doses can lead to treatment failure.

Using a form of evolutionary modelling, Cleveland Clinic researchers can predict what happens if you miss a dose of antibiotics.

.A team led by Jacob Scott, MD, DPhil., including study first author Eshan King, an MD/PhD student at Case Western Reserve University School of Medicine, is refining models that determine recommended antibiotic doses by incorporating bacterial evolutionary dynamics.

"With the rise of...