Los Angeles, Dec. 18 -- Actress Meg Ryan has broken her silence on the tragic deaths of filmmaker Rob Reiner and his wife Michele Reiner, saying she hopes their story leads to greater awareness and understanding despite the "impossible tragedy," reported People.

Taking to Instagram, Ryan paid an emotional tribute to the late filmmaker, with whom she worked in the iconic romantic comedy When Harry Met Sally. Sharing a throwback photograph, the actress wrote, "Oh how we will miss this man...," the actress, 64, wrote on Instagram, alongside a throwback photo of herself dancing with the When Harry Met Sally director.

Ryan also acknowledged the couple's larger values, writing, "Thank you, Rob and Michele, for the way you believe in true love...