US Patent Issued to Zymeworks BC on July 15 for "Anti-HER2 biparatopic antibody-drug conjugates and methods of use" (Canadian, American Inventors)

ALEXANDRIA, Va., July 16 -- United States Patent no. 12,357,701, issued on July 15, was assigned to Zymeworks BC Inc. (Vancouver, Canada).

"Anti-HER2 biparatopic antibody-drug conjugates and methods of use" was invented by Kevin Hamblett (Seattle), Rupert H. Davies (Seattle), James R. Rich (Vancouver, Canada), Gerald J. Rowse (New Westminster, Canada), Vincent K. C. Fung (Vancouver, Canada) and Stuart D. Barnscher (Vancouver, Canada).

According to the abstract* released by the U.S. Patent & Trademark Office: "Anti-HER2 biparatopic antibody-drug conjugates (ADCs) in which the drug is an auristatin analogue and is conjugated to the antibody at a low average drug-to-antibody ratio (DAR), and methods of using the ADCs in the treatment of a HE...