ALEXANDRIA, Va., June 4 -- United States Patent no. 12,318,458, issued on June 3, was assigned to Wisconsin Alumini Research Foundation (Madison, Wis.).

"PSMA-targeting ligands with optimal properties for imaging and therapy" was invented by Reinier Hernandez (Madison, Wis.) and Anatoly Pinchuk (Orinda, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Theranostic agents incorporating a chelating moiety that can chelate a radioactive metal isotope and a PSMA-targeting moiety are disclosed herein. The theranostic agents, which can be used to treat and/or detect cancers associated with increased PSMA expression, have the formula:and include complexes, anions or salts thereof. R1 includes a chelating moiety...