US Patent Issued to Washington University on March 11 for "Identification of inhibitors of TcpC and TIR NADase activity" (Missouri Inventors)

ALEXANDRIA, Va., March 12 -- United States Patent no. 12,247,246, issued on March 11, was assigned to Washington University (St. Louis).

"Identification of inhibitors of TcpC and TIR NADase activity" was invented by Jeffrey D. Milbrandt (St. Louis), Aaron DiAntonio (St. Louis), Kow Essuman (St. Louis), Xianrong Mao (St. Louis), Yo Sasaki (St. Louis) and Dan Summers (St. Louis).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides compounds useful as inhibitors of TIR NADase activity, compositions thereof, and methods of using the same. The present invention is useful for inhibition of TIR-domain NADase activity and/or treating microbial infection and/or modulating microbial physiology....