US Patent Issued to VYCELLIX on Jan. 27 for "Enhanced gene delivery to natural killer cells, hematopoietic stem cells and macrophages" (Swedish, Turkish, American Inventors)

ALEXANDRIA, Va., Jan. 28 -- United States Patent no. 12,533,338, issued on Jan. 27, was assigned to VYCELLIX INC. (Boca Raton, Fla.).

"Enhanced gene delivery to natural killer cells, hematopoietic stem cells and macrophages" was invented by Evren Alici (Nykoping, Sweden), Adil Duru (Pembroke Pines, Fla.) and Tolga Sutlu (Kadikoy Istanbul, Turkey).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention comprises a method of downregulating intracellular defenses by administering (5Z)-7-Oxozeaenol. This allows for improved delivery of RNA based gene vectors to natural killer, stem and macrophage cells. The resulting cells can be used in adoptive cell transfer therapies. Also provided are methods of ...