US Patent Issued to USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR V.V.I. on April 8 for "Cyclen based compounds, coordination compounds, peptides, pharmaceutical preparation, and use thereof" (Czech Inventors)

ALEXANDRIA, Va., April 9 -- United States Patent no. 12,268,757, issued on April 8, was assigned to USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR V.V.I. (Prague).

"Cyclen based compounds, coordination compounds, peptides, pharmaceutical preparation, and use thereof" was invented by Miloslav Polasek (Prague) and Jan Kretschmer (Prague).

According to the abstract* released by the U.S. Patent & Trademark Office: "Cyclen based compounds of general formula (I) are disclosed. X is nitrogen and Y, Z are -CH-, or X, Z are -CH- and Y is nitrogen, or X, Y are -CH- and Z is nitrogen. R1 is independently selected from H; COOH; benzyloxycarbonyl; fluorenylmethyloxycarbonyl; tert-butoxycarbonyl; methylcarbonyl; trifluoromethylcarbonyl; benzyl; triphenylmeth...