US Patent Issued to USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. on July 29 for "Compounds for inhibition of fibroblast activation protein" (Czech Inventors)

ALEXANDRIA, Va., July 30 -- United States Patent no. 12,371,416, issued on July 29, was assigned to USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (Prague).

"Compounds for inhibition of fibroblast activation protein" was invented by Adela Simkova (Prague), Pavel Sacha (Prague), Natan Sidej (Prague), Tereza Ormsby (Prague) and Jan Konvalinka (Prague).

According to the abstract* released by the U.S. Patent & Trademark Office: "Quinolinecarboxamide compounds of general formula I exceed the previously known FAP inhibitors in affinity and inhibitory effect. These agents can be used to specifically target tumours for diagnostic and therapeutic purposes, or for laboratory purposes in the study of endogenous FAP expression."

The patent was fil...