US Patent Issued to University of Tennessee Research Foundation on June 17 for "Bromodomain inhibitors to target therapy-resistant cancer" (Tennessee Inventors)

ALEXANDRIA, Va., June 19 -- United States Patent no. 12,329,755, issued on June 17, was assigned to University of Tennessee Research Foundation (Knoxville, Tenn.).

"Bromodomain inhibitors to target therapy-resistant cancer" was invented by Duane Miller (Memphis, Tenn.), Lawrence M. Pfeffer (Memphis, Tenn.), Yali He (Memphis, Tenn.) and Debolina Ganguly (Memphis, Tenn.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Novel inhibitors of the bromodomain of Brahma-related gene 1 (BRG1) are described. Also described are methods of treating glioblastoma using inhibitors of the BRG1 bromodomain in combination with chemotherapeutics, such as DNA alkylating agents. As described herein, the inhibitors sensitize gliobla...