US Patent Issued to University of Tennessee Research Foundation on Aug. 5 for "Metabolically stable pyrimidinyl dihydroquinoxalinones as tubulin polymerization inhibitors" (Arkansas, Tennessee Inventors)

ALEXANDRIA, Va., Aug. 6 -- United States Patent no. 12,378,257, issued on Aug. 5, was assigned to University of Tennessee Research Foundation (Knoxville, Tenn.).

"Metabolically stable pyrimidinyl dihydroquinoxalinones as tubulin polymerization inhibitors" was invented by Souvik Banerjee (Fort Smith, Ark.), Wei Li (Germantown, Tenn.), Duane D. Miller (Collierville, Tenn.), Zhongzhi Wu (Collierville, Tenn.) and Satyanarayana Pochampally (Memphis, Tenn.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention encompasses novel dihydroquinoxalinone compounds with significantly improved water solubility and reduced toxicity to achieve higher therapeutic indexes and the treatment of cancer, virus infections, a...