ALEXANDRIA, Va., Oct. 28 -- United States Patent no. 12,449,494, issued on Oct. 21, was assigned to University Of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh).

"Chemical exchange saturation transfer (CEST) magnetic resonance imaging using an ASEF or AROSE system" was invented by Tao Jin (Wexford, Pa.) and Julius Chung (Pittsburgh).

According to the abstract* released by the U.S. Patent & Trademark Office: "A method for chemical exchange saturation transfer (CEST) MRI using an average saturation efficiency filter (ASEF)/adjustment of rotation and saturation effects (AROSE) includes: applying a first RF pulse train including a high duty cycle, the first RF pulse causing magnetization of exchangeable protons based o...