US Patent Issued to University of Pittsburgh-Of the Commonwealth System of Higher Education on Nov. 25 for "20-HETE formation inhibitors" (Pennsylvania Inventors)

ALEXANDRIA, Va., Nov. 25 -- United States Patent no. 12,479,816, issued on Nov. 25, was assigned to University of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh).

"20-HETE formation inhibitors" was invented by Lee Apostle McDermott (Pittsburgh), David Koes (Pittsburgh), Samuel M. Poloyac (Pittsburgh) and Shabber Mohammed (Pittsburgh).

According to the abstract* released by the U.S. Patent & Trademark Office: "This disclosure provides novel heterocyclic compounds and methods for inhibiting the enzyme CYP4. Further disclosed methods include: a method of inhibiting the biosynthesis of 20-hydroxyeicosatetraenoic acid (20-HETE) in a subject in need thereof and a method of producing neuroprotection and decreased brain dam...