US Patent Issued to UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION on March 11 for "Oncolytic viruses targeting STAT3" (Pennsylvania Inventors)

ALEXANDRIA, Va., March 12 -- United States Patent no. 12,246,049, issued on March 11, was assigned to UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh).

"Oncolytic viruses targeting STAT3" was invented by Stephen Howard Thorne (Pittsburgh) and Daniel J. Byrd (Pittsburgh).

According to the abstract* released by the U.S. Patent & Trademark Office: "This disclosure relates to modified viruses, e.g., oncolytic vaccinia viruses, which have been modified to contain an exogenous nucleic acid that expresses a protein that modulates STAT3 activity. It is based, at least in part, on the discovery that vaccinia viruses modified to contain nucleic acid encoding PIAS3 and that express PIAS3 or a fragment thereof ca...