US Patent Issued to University of Massachusetts, Voyager Therapeutics on March 18 for "Closed-ended linear duplex DNA for non-viral gene transfer" (Massachusetts Inventors)

ALEXANDRIA, Va., March 19 -- United States Patent no. 12,252,703, issued on March 18, was assigned to University of Massachusetts (Westborough, Mass.) and Voyager Therapeutics (Cambridge, Mass.).

"Closed-ended linear duplex DNA for non-viral gene transfer" was invented by Robert M. Kotin (Worcester, Mass.) and Sylvain Cecchini (Worcester, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Aspects of the disclosure relate to a nucleic acid comprising a heterologous nucleic acid insert flanked by interrupted self-complementary sequences, wherein one self-complementary sequence is interrupted by a cross-arm sequence forming two opposing, lengthwise-symmetric stem-loops, and wherein the other of the self-compl...