US Patent Issued to UNIVERSITY OF MARYLAND, COLLEGE PARK on Dec. 16 for "Endo-S2 mutants as glycosynthases, method of making and use for glycoengineering of glycoproteins" (Maryland Inventors)

ALEXANDRIA, Va., Dec. 16 -- United States Patent no. 12,497,643, issued on Dec. 16, was assigned to UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Md.).

"Endo-S2 mutants as glycosynthases, method of making and use for glycoengineering of glycoproteins" was invented by Lai-Xi Wang (Ellicott City, Md.), Qiang Yang (Ellicott City, Md.), Tiezheng Li (Columbia, Md.) and Xin Tong (College Park, Md.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides for the use of recombinant Endo-S2 mutants (named Endo-S2 glycosynthases) that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sugar chain is added to a fu...