US Patent Issued to University of Kentucky Research Foundation on Dec. 2 for "Mithramycin oxime derivatives having increased selectivity and anti-cancer activity" (American, Chinese Inventors)

ALEXANDRIA, Va., Dec. 2 -- United States Patent no. 12,486,300, issued on Dec. 2, was assigned to University of Kentucky Research Foundation (Lexington, Ky.).

"Mithramycin oxime derivatives having increased selectivity and anti-cancer activity" was invented by Jon S. Thorson (Lexington, Ky.), Jurgen Rohr (Lexington, Ky.), Markos Leggas (Lexington, Ky.), Joseph M. Eckenrode (Lexington, Ky.), Yinan Zhang (Jiangsu, China), Yang Liu (Lexington, Ky.), Jianjun Zhang (Lexington, Ky.) and Khaled Attia Shaaban Mahmoud (Lexington, Ky.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Compounds described herein are mithramycin (MTM) oxide (OX) derivatives. These compounds are useful for treatment of cancers and neuro-dise...