US Patent Issued to University of Florida Research Foundation on Nov. 18 for "Regulation of RAN translation by PKR and eIF2Alpha-P pathways" (Florida Inventors)

ALEXANDRIA, Va., Nov. 18 -- United States Patent no. 12,473,545, issued on Nov. 18, was assigned to University of Florida Research Foundation Inc. (Gainesville, Fla.).

"Regulation of RAN translation by PKR and eIF2Alpha-P pathways" was invented by Laura Ranum (Gainesville, Fla.) and Tao Zu (Gainesville, Fla.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Methods and compositions for modulating repeat non-ATG protein (RAN protein) translation are provided. In some aspects, the disclosure provides methods of inhibiting RAN protein translation by contacting a cell with an effective amount of an inhibitor of eIF2 phosphorylation or an inhibitor of protein kinase R (PKR). In some embodiments, methods described by...