ALEXANDRIA, Va., April 2 -- United States Patent no. 12,262,983, issued on April 1, was assigned to University of Cincinnati (Cincinnati) and Children's Hospital Medical Center (Cincinnati).

"System and method for detecting small blood-tissue barrier disruption" was invented by Jinghua Wang (Mason, Ohio) and Lili He (Mason, Ohio).

According to the abstract* released by the U.S. Patent & Trademark Office: "A method for detecting blood-tissue barrier breakdown or disruption is provided. The method includes acquiring first image data of a target region of a subject with a predetermined spatial resolution; administrating exogenous or endogenous tracer into the subject; acquiring second image data of the target region with the predetermined sp...