US Patent Issued to UNIVERSIDAD AUSTRAL DE CHILE on Oct. 28 for "TFEB mutants and their use in the treatment and/or prevention of disorders that require the induction of the cellular autophagy-lysosomal system" (Chilean Inventors)

ALEXANDRIA, Va., Oct. 28 -- United States Patent no. 12,454,558, issued on Oct. 28, was assigned to UNIVERSIDAD AUSTRAL DE CHILE (Valdivia, Chile).

"TFEB mutants and their use in the treatment and/or prevention of disorders that require the induction of the cellular autophagy-lysosomal system" was invented by Alejandro Rojas-Fernandez (Valdivia, Chile), Patricia Burgos (Valdivia, Chile) and Alexis Gonzalez (Valdivia, Chile).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention relates to constitutively active mutants of the transcription factor TFEB, which can mutate the lysine of one or both sites of positions 219 and 347; and/or also mutate the glutamic acid of one or both sites of positions 221 and ...