ALEXANDRIA, Va., March 26 -- United States Patent no. 12,258,316, issued on March 25, was assigned to THERAVANCE BIOPHARMA R&D IP LLC (South San Francisco, Calif.).

"Biphenyl compounds useful as muscarinic receptor antagonists" was invented by Mathai Mammen (Menlo Park, Calif.), YuHua Ji (Palo Alto, Calif.), YongQi Mu (Los Altos, Calif.), Craig Husfeld (Redwood City, Calif.) and Li Li (Sunnyvale, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "This invention provides compounds of formula I:wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutica...