US Patent Issued to The University of North Carolina at Chapel Hill on Nov. 25 for "Chimeric antigen receptor constructs and their use in CAR-T cells" (North Carolina Inventor)

ALEXANDRIA, Va., Nov. 25 -- United States Patent no. 12,479,890, issued on Nov. 25, was assigned to The University of North Carolina at Chapel Hill (Chapel Hill, N.C.).

"Chimeric antigen receptor constructs and their use in CAR-T cells" was invented by Lishan Su (Chapel Hill, N.C.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention is directed to chimeric antigen receptor (CAR) compositions and methods of their use in cancer and anti-viral immunotherapy. In particular, the CAR of the invention comprises a costimulatory signal (CSS) domain comprising herpes virus entry mediator protein (HVEM) or a functional fragment or variant thereof. CARs comprising such a HVEM CSS exhibit enhanced effecto...