US Patent Issued to The University of North Carolina at Chapel Hill on Jan. 28 for "Modified adeno-associated virus 5 capsids and uses thereof" (North Carolina Inventors)

ALEXANDRIA, Va., Jan. 29 -- United States Patent no. 12,209,251, issued on Jan. 28, was assigned to The University of North Carolina at Chapel Hill (Chapel Hill, N.C.).

"Modified adeno-associated virus 5 capsids and uses thereof" was invented by Xiao Xiao (Chapel Hill, N.C.), Randolph Qian (Chapel Hill, N.C.) and Juan Li (Chapel Hill, N.C.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides mutant adeno-associated virus serotype 5 (AAV5) that exhibit altered capsid properties, e. g., increased infectivity in human liver cells and/or minimal binding to human neutralizing antibodies. The present invention further provides libraries of mutant AAV5 comprising one or more mutations in a ...