US Patent Issued to The University of North Carolina at Chapel Hill on April 22 for "Methods and compositions for delivery of viral vectors across the blood-brain barrier" (North Carolina Inventors)

ALEXANDRIA, Va., June 6 -- United States Patent no. 12,281,335, issued on April 22, was assigned to The University of North Carolina at Chapel Hill (Chapel Hill, N.C.).

"Methods and compositions for delivery of viral vectors across the blood-brain barrier" was invented by Chengwen Li (Chapel Hill, N.C.) and Richard Jude Samulski (Chapel Hill, N.C.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed herein is an adeno-associated virus (AAV) particle comprising a surface-bound peptide that enhances transduction of cells across the blood-brain barrier (BBB). Also disclosed herein is a modified AAV capsid protein comprising an insertion of a polypeptide that enhances transduction of cells across the BBB, an...