US Patent Issued to The United States of America, as represented by the Secretary, Department of Health and Human Services on Oct. 14 for "Adeno-associated virus vectors encoding modified G6PC and uses thereof" (Maryland Inventor)

ALEXANDRIA, Va., Oct. 21 -- United States Patent no. 12,440,580, issued on Oct. 14, was assigned to The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Md.).

"Adeno-associated virus vectors encoding modified G6PC and uses thereof" was invented by Janice J. Chou (North Bethesda, Md.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Modified G6PC (glucose-6-phosphatase, catalytic subunit) nucleic acids and glucose-6-phosphatase-Alpha (G6Pase-Alpha) enzymes with increased phosphohydrolase activity are described. Also described are vectors, such as adeno-associated virus (AAV) vectors, and recombinant AAV expressing modified G6Pase-Alpha. The disclosed A...