US Patent Issued to The United States of America, as represented by the Secretary, Department of Health and Human Services on Aug. 5 for "A1 adenosine receptor agonists and methods of use thereof" (Maryland Inventors)

ALEXANDRIA, Va., Aug. 6 -- United States Patent no. 12,378,248, issued on Aug. 5, was assigned to The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Md.).

"A1 adenosine receptor agonists and methods of use thereof" was invented by Kenneth A. Jacobson (Silver Spring, Md.), Dilip K. Tosh (Rockville, Md.), Marc L. Reitman (Potomac, Md.) and Oksana Gavrilova (Bethesda, Md.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed are compounds of the formulas (I), (II), and (II): which are A1 adenosine receptor agonists, pharmaceutical compositions comprising such compounds, and a method of use of these compounds, wherein Y, R1-R6, R10-R15, and R20-R2...