US Patent Issued to The Trustees of the University of Pennsylvania on Sept. 23 for "Compositions and methods for selective phagocytosis of human cancer cells" (Pennsylvania, California Inventors)

ALEXANDRIA, Va., Sept. 23 -- United States Patent no. 12,421,495, issued on Sept. 23, was assigned to The Trustees of the University of Pennsylvania (Philadelphia).

"Compositions and methods for selective phagocytosis of human cancer cells" was invented by Dennis E. Discher (Philadelphia), Kyle R. Spinler (La Jolla, Calif.) and Cory Alvey (Philadelphia).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to compositions and methods that provide novel therapies in cancer. The invention includes a phagocytic cell modified with a repressor of signal regulatory protein-alpha (SIRPAlpha) and bound to a targeting antibody to enhance phagocytic activity of the phagocytic cell toward tumor ti...