ALEXANDRIA, Va., March 19 -- United States Patent no. 12,251,476, issued on March 18, was assigned to The Trustees of the University of Pennsylvania (Philadelphia).

"Mechano-sensitive microcapsules for drug delivery" was invented by Daeyeon Lee (Wynnewood, Pa.), Robert Leon Mauck (Philadelphia), George R Dodge (Philadelphia), Fuquan Tu (Philadelphia) and Bhavana Mohanraj (Philadelphia).

According to the abstract* released by the U.S. Patent & Trademark Office: "Embodiments of the present invention relate to mechanically-activated microcapsules (MAMCs) for controlled drug-delivery, wherein the MAMCs release one or more active ingredients in response to mechanical stimuli in a subject's body. The MAMCs provide a platform for stimulating bio...