US Patent Issued to The Trustees of the University of Pennsylvania on June 10 for "Use of trans-signaling approach in chimeric antigen receptors" (Pennsylvania Inventors)

ALEXANDRIA, Va., June 18 -- United States Patent no. 12,325,756, issued on June 10, was assigned to The Trustees of the University of Pennsylvania (Philadelphia).

"Use of trans-signaling approach in chimeric antigen receptors" was invented by Daniel J. Powell Jr. (Bala Cynwyd, Pa.) and Carl H. June (Merion Station, Pa.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides compositions and methods for inducing a CAR mediated trans-signal in a T cell. The trans-signaling CAR T cells comprise a first CAR having a first signaling module and a second CAR having a distinct second signaling module. The present invention also provides cells comprising a plurality of types of CARs, wherein the...