US Patent Issued to The Trustees of the University of Pennsylvania on July 1 for "Altering gene expression in cart cells and uses thereof" (Pennsylvania, New Jersey Inventors)

ALEXANDRIA, Va., July 3 -- United States Patent no. 12,344,843, issued on July 1, was assigned to The Trustees of the University of Pennsylvania (Philadelphia).

"Altering gene expression in cart cells and uses thereof" was invented by Yangbing Zhao (Lumberton, N.J.), Jiangtao Ren (Philadelphia), Xiaojun Liu (Wallingford, Pa.) and Carl H. June (Merion Station, Pa.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to compositions and methods for generating a modified T cell with a nucleic acid capable of downregulating endogenous gene expression selected from the group consisting of TCR Alpha chain, TCR Beta chain, beta-2 microglobulin, a HLA molecule, CTLA-4, PD1, and FAS and furthe...