ALEXANDRIA, Va., June 19 -- United States Patent no. 12,329,816, issued on June 17, was assigned to The Trustees of Princeton University (Princeton, N.J.) and The Trustees of the University of Pennsylvania (Philadelphia).

"Immunotherapy with metabolic enzyme expression" was invented by Joshua D. Rabinowitz (Princeton, N.J.) and Roderick O'Connor (Philadelphia).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides, in some embodiments, methods of promoting an immune response in a subject in need thereof, comprising administering to the subject a population of immune cells that express an enzyme that facilitates immune cell function in a nutrient-poor environment. The invention also prov...