ALEXANDRIA, Va., Feb. 19 -- United States Patent no. 12,227,779, issued on Feb. 18, was assigned to THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Ind.).

"Modified DDAH polypeptides and their use to extracorporeally treat a patient's blood to reduce levels of ADMA" was invented by Jaipal Singh (Carmel, Ind.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Modified DDAH polypeptides and their uses thereof are provided. Exemplary embodiments provide DDAH polypeptides which include one or more amino acid substitutions, additions, or deletions with natural or non-naturally encoded amino acids, and/or linkage to other biologically active molecules including other DDAH polypeptides, as well as PKEM. Additionally, ...