ALEXANDRIA, Va., Sept. 3 -- United States Patent no. 12,404,277, issued on Sept. 2, was assigned to THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York).

"Substituted 4-phenylpiperidines, their preparation and use" was invented by Konstantin Petrukhin (New Windsor, N.Y.), Graham Johnson (Sanbornton, N.H.), Rando Allikmets (Cornwall on Hudson, N.Y.), Christopher Cioffi (Albany, N.Y.), Emily Freeman (Albany, N.Y.), Ping Chen (Albany, N.Y.), Michael Conlon (Albany, N.Y.) and Lei Zhu (Albany, N.Y.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl, whe...