US Patent Issued to The Trustees of Columbia University in the City of New York on May 27 for "Compositions and methods for using engineered deubiquitinases for probing ubiquitin-dependent cellular processes" (New York, New Jersey Inventors)

ALEXANDRIA, Va., June 17 -- United States Patent no. 12,312,618, issued on May 27, was assigned to The Trustees of Columbia University in the City of New York (New York).

"Compositions and methods for using engineered deubiquitinases for probing ubiquitin-dependent cellular processes" was invented by Henry M. Colecraft (Robbinsville, N.J.) and Scott Kanner (New York).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides, inter alia, a recombinant engineered deubiquitinase (DUB) and methods for treating or ameliorating an inherited ion channelopathy, such as long QT syndrome, Brugada syndrome, or cystic fibrosis, in a subject. Further provided are methods for screening mutations causin...