ALEXANDRIA, Va., March 19 -- United States Patent no. 12,251,392, issued on March 18, was assigned to The Trustees of Columbia University in the City of New York (New York).
"Deoxynucleoside therapy for diseases caused by unbalanced nucleotide pools including mitochondrial DNA depletion syndromes" was invented by Michio Hirano (New York), Caterina Garone (Cambridge, Great Britain) and Ramon Marti (Barcelona, Spain).
According to the abstract* released by the U.S. Patent & Trademark Office: "The invention relates generally to a pharmacological therapy for human genetic diseases, specifically those characterized by unbalance nucleotide pools, more specifically mitochondrial DNA depletion syndromes, and more specifically, thymidine kinase 2 ...