US Patent Issued to The Scripps Research Institute on April 22 for "Method for the site-specific enzymatic labelling of nucleic acids in vitro by incorporation of unnatural nucleotides" (American, Chinese, French Inventors)

ALEXANDRIA, Va., June 6 -- United States Patent no. 12,281,137, issued on April 22, was assigned to The Scripps Research Institute (La Jolla, Calif.).

"Method for the site-specific enzymatic labelling of nucleic acids in vitro by incorporation of unnatural nucleotides" was invented by Floyd E. Romesberg (La Jolla, Calif.), Denis A. Malyshev (Solana Beach, Calif.), Lingjun Li (San Diego), Thomas Lavergne (Le Versoud, France) and Zhengtao Li (Pudong new district, China).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are analogs of unnatural nucleotides bearing predominantly hydrophobic nucleobase analogs that form unnatural base pairs during DNA polymerase-mediated replication of DNA or RNA poly...