US Patent Issued to The Regents of the University of Michigan on Oct. 28 for "Activating mitotic checkpoint control mechanisms" (Michigan, Tennessee Inventors)

ALEXANDRIA, Va., Oct. 28 -- United States Patent no. 12,454,559, issued on Oct. 28, was assigned to The Regents of the University of Michigan (Ann Arbor, Mich.).

"Activating mitotic checkpoint control mechanisms" was invented by Ajit P. Joglekar (Ann Arbor, Mich.) and Pavithra Aravamudhan (Nashville, Tenn.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are compositions and methods for the treatment of cancer by activating the spindle assembly checkpoint (SAC) in cells. In particular, dimerized Mps1 and Spc105/KNL1 constructs are provided as tunable activators of SAC, allowing for control of chromosome segregation accuracy and prevention of aneuploidies that are common in cancer."

The patent ...