US Patent Issued to The Regents of the University of Michigan on April 29 for "ASH1L degraders and methods of treatment therewith" (Michigan Inventors)

ALEXANDRIA, Va., June 9 -- United States Patent no. 12,285,490, issued on April 29, was assigned to The Regents of the University of Michigan (Ann Arbor, Mich.).

"ASH1L degraders and methods of treatment therewith" was invented by Jolanta Grembecka (Ann Arbor, Mich.), Szymon Klossowski (Ann Arbor, Mich.), Jing Deng (Ann Arbor, Mich.), Tomasz Cierpicki (Ann Arbor, Mich.), Hao Li (Ann Arbor, Mich.), Hongzhi Miao (Ann Arbor, Mich.), Trupta Purohit (Ann Arbor, Mich.), EunGi Kim (Ann Arbor, Mich.) and Dong Chen (Ann Arbor, Mich.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are small molecules comprising a first domain that binds to ASH1L and a second domain that facilitates ASH1L degradation. In...