US Patent Issued to The Regents of the University of California on Sept. 30 for "Cancer treatment targeted to tumor adaptive responses to protein synthesis stress" (California Inventors)

ALEXANDRIA, Va., Sept. 30 -- United States Patent no. 12,427,148, issued on Sept. 30, was assigned to The Regents of the University of California (Oakland, Calif.).

"Cancer treatment targeted to tumor adaptive responses to protein synthesis stress" was invented by Davide Ruggero (Emerald Hill, Calif.), Hao Nguyen (San Francisco), Peter Carroll (San Francisco) and Crystal Conn (Oakland, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "In cancers such as prostate cancer, the combination of PTEN loss and activation of Myc activates an adaptive stress response that enables tumor cells to escape the stress of massively upregulated protein synthesis. This pro-survival response is mediated by the PERK-phosphor...