US Patent Issued to The Regents of the University of California on Sept. 23 for "Genetic modification of mammalian cells to confer resistance to CSF1R antagonists" (California Inventors)

ALEXANDRIA, Va., Sept. 23 -- United States Patent no. 12,421,517, issued on Sept. 23, was assigned to The Regents of the University of California (Oakland, Calif.).

"Genetic modification of mammalian cells to confer resistance to CSF1R antagonists" was invented by Mathew Blurton-Jones (Irvine, Calif.), Jean Paul Chadarevian (Irvine, Calif.), Robert Spitale (Irvine, Calif.), Sunil Gandhi (Irvine, Calif.), Whitney England (Irvine, Calif.), Hayk Davtyan (Irvine, Calif.) and Jonathan Hasselmann (Irvine, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Microglia/monocytes exist within a 'niche' which limits the total number of microglia/monocytes/macrophages that reside within a mammalian central nervous sys...