US Patent Issued to The Regents of the University of California on Sept. 23 for "Diverse and flexible chemical modification of nucleic acids" (California Inventors)

ALEXANDRIA, Va., Sept. 23 -- United States Patent no. 12,421,266, issued on Sept. 23, was assigned to The Regents of the University of California (Oakland, Calif.).

"Diverse and flexible chemical modification of nucleic acids" was invented by Navtej Toor (La Jolla, Calif.) and Anastassia Hirlinger (La Jolla, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides a method for chemically modifying a nucleic acid molecule using sulfinate reagents to increase stability in vitro and in vivo. Screening methods for nucleobase modifications that reduce cleavage of a nucleic acid molecule by a nuclease are also provided."

The patent was filed on Sept. 26, 2019, under Application No. 17/...